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脂连素球状域与糖尿病及其心血管并发症关系

Role of Globular Adiponectin in Diabetes and Its Cardiovascular Complications
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摘要 作为脂连素的活性部位,脂连素球状域能够调节糖脂代谢、改善胰岛素抵抗和保护胰岛β细胞;另外脂连素球状域还具有保护心血管系统和抗炎症的作用。但近年来又有研究认为脂连素球状域具有促炎症的作用,这可能会限制其临床的应用。 As an active fragment of adiponectin,globular adiponectin could regulate the glucose and lipids metabolism,ameliorate insulin resistance and protect pancreatic β-cells.Besides,globular adiponectin exerts cardiovascular protection and anti-inflammatory effects.But in recent years,the pro-inflammatory effects of globular adiponectin were observed,which might limit its application in clinic.
作者 刘文超 高向东
机构地区 中国药科大学生命科学与技术学院
出处 《药学与临床研究》 2011年第4期327-331,共5页 Pharmaceutical and Clinical Research
基金 国家自然科学基金(No.30973667)
关键词 脂连素 脂连素球状域 糖尿病 心血管疾病 分子机制 Adiponectin Globular adiponectin Diabetes Cardiovascular disease Molecular mechanisms
分类号 R977.15 [医药卫生—药品]
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参考文献32

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药学与临床研究
2011年 第4期

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