高容量血液滤过对心肺复苏后综合征患者的影响

目的评价高容量血液滤过(High Volume Hemofiltration,HVHF)对心肺复苏后综合征(post-resuscitation syndrome,PRS)患者的影响。方法 32例PRS患者,随机分为治疗组和对照组,治疗组在对照组常规治疗的基础上,加用HVHF治疗,对比治疗前后多巴胺用量、平均动脉压(MAP)、氧合指数(PaO2/FiO2)、血乳酸、C反应蛋白(CRP)、APACHEⅡ评分、GCS评分等及14天及30天病死率。结果 HVHF治疗后,治疗组MAP、PaO2/FiO2、GCS评分升高,多巴胺用量、血乳酸、CRP、APACHEⅡ评分、14天病死率下降,与对照组比较,差异具有显著统计学意义(P<0.05),30天病死率两组无统计学差异。结论 HVHF对PRS的治疗有益,可以降低近期死亡率,但不能改善患者远期预后。

Objective To evaluate the effect of High Volume Hemofiltration（HVHF） in the treatment of post-resuscitation syndrome（PRS） Methods 32 patients were divided into the therapy group and the control group randomly.All groups were given routine therapy while the therapy group was given HVHF for seven days.The dosage of Dopamine,mean arterial pressure（MAP）,oxygenation index（PaO2/FiO2）,blood lactate,c-reaction protein（CRP）,score of acute physiology and chronic health evaluation Ⅱ（APACHEⅡ）,glasgow coma score（GCS）,motality in fourteen and thirty days were recorded.Results After treatment,compared with the control group,MAP,PaO2/FiO2,score of GCS increased while the dosage of Dopamine,blood lactate,CRP,score of APACHEⅡ and Motality in fourteen days decreased significantly（P〈0.05）.The motality rate in thirty days has no difference in the two groups.Conclusion HVHF is effective in the treatment of PRS and can decrease the motality in short time,but has no effect on the prognosis.