恶性血液病患儿深部真菌感染调查

Survey of deep fungus infection in children with malignant hematological disease

目的了解院内恶性血液病患儿深部真菌感染的临床和病原学特点。方法 2008年6月～2011年5月对91例住院恶性血液病患儿进行前瞻性研究。结果 3年期间恶性血液病患儿中10例感染深部真菌病,共分离出12株真菌,以白色念珠菌和热带念珠菌为主,感染部位以肺部为主,亦见血液、消化道和其他部位。其发生与持续白细胞计数<1.0×109/L>7d,2种及2种以上广谱抗生素联合应用>5d,化疗时间>3月,肿瘤复发有关。结论了解上述恶性血液病患儿深部真菌感染的病原学特点和警惕相关危险因素对临床防治深部真菌病具有重要意义。

Objetive To investigate etiology and clinical manifestations of childhood malignant hemopathy.Methods Ninety-one children with malignant hematological diseases were surveyed from June,2008 to May,2011.Results Ten of the ninety-one children with malignant hematological disease developed invasive fungal infection,mainly Candida albicans and Candida tropicalis.The systems of lung,blood and digestive,etc.were involved.The susceptible factor relating to constantly low white blood cell count,more than 3 months of chemotherapy,longer than 5 days of combined using broad spectrum antibiotics,the relapse of the primary disease.Conclusion laboratory test be carried before clinical treatment of fungal infection is made.