人乳头瘤病毒与解脲支原体感染关系的临床观察

Clinical observation on the relationship between human papillomavirus infection and Ureaplasma urealyticum infection

目的探讨人乳头瘤病毒(HPV)感染与解脲支原体(UU)感染的关系。方法对177例妇产科门诊就诊患者,采用PCR技术检测筛查UU,检查HPVDNA及其基因分型,观察其感染率,又设UU检出阳性者为观察组,设UU检出阴性者为对照组,两组进行HPV阳性率的对比分析。结果 UU的感染率为29.3%(52/177);HPV的感染率为31.6%(56/177),共检出21个不同的亚型,HPV高危型和可能高危型31例,占55.4%(31/56);HPV低危型16例,占28.6%(16/56);未知危险型7例,占13.4%(7/56);观察组HPV阳性率为42.3%(22/52),对照组的HPV阳性率为27.2%(34/125),两组比较,差异有统计学意义(P<0.05)。结论解脲支原体(UU)感染与人乳头瘤病毒(HPV)感染具有相关性,可能会增加人乳头瘤病毒(HPV)感染的机会。

Objective To explore the relationship between human papillomavirus（HPV） infection and Ureaplasma urealyticum（UU） infection.Methods There 177 cervical sampales were collected and detected for HPV and UU infectionss in gynecology and obstetrics outpatients.UU infection was screened with PCR,HPV DNA and genotyping were conducted with PCR.The patients negative for UU were as control group,and those positive for UU positive were as the observation group.Results The infection rate of UU and HPV were 29.3%（52/177）,31.6%（56/177）,respectedly.21 different kind subtype of HPV was recorded.There were 31 high-risk and probably high-risk HPV cases（55.4%）（including HPV 16 in 8 cases,HPV 58 in 5 cases,HPV 31 in 4 cases,HPV 53 in 4 cases,HPV 33 in 3 cases,HPV 52 in 2 cases,HPV 66 in 2 cases,HPV 3in 2 cases,HPV 51 in 1 cases,HPV 56 in 1 cases,HPV 68 in 1 cases）.The were 16 low-risk HPV cases（28.6%）（including HPV 6 in 4 cases,HPV 42 in 4 cases,HPV 54 in 3 cases,HPV 70 in 3 cases,HPV 61 in1 cases,HPV 81 in 1 cases）.There were also 7 unknown-risk HPV cases（13.4%）（including HPV 87 in 3 cases,HPV 84 in 2 cases,HPV 74 in 1 cases,HPV 30 in 1 cases.The HPV positive rates in the observation group and control group were 42.3%（22/52） and 27.2%（34/125） showing significant difference（P0.05）.Conclusion HPV infection is associated with UU infection.UU infection may increase the chance of HPV infection.