复方苦参注射液防治放射性口炎的临床研究

Efficacy of compound radix sophorae flavescentis injection in the prevention of radiation stomatitis

目的:观察应用复方苦参注射液防治放射性口炎患者的临床效果。方法:应用复方苦参注射液联合放疗的头颈部肿瘤患者30例,与单纯放疗头颈部肿瘤患者30例对照,比较两组患者口腔黏膜的溃疡表现及疼痛指数。结果:研究组患者的口腔黏膜破溃程度及疼痛指数均明显低于对照组,差异具有统计学意义。结论:复方苦参注射液预防用药可推迟放射性口腔炎的发生、改善其临床症状,是防治疗放射性口炎的有效方法。

Objective： To evaluate the efficacy of compound radix sophorae flavescentis injection in the prevention of radiation stomatitis. Methods： Totally 30 patients with head and neck cancers were assigned to receive radiotherapy plus compound radix sophorae flaveseentis injection （n = 30） and radiotherapy alone （control, n = 30）. The pain index and oral uleer were observed. Results： Pain index and oral ulcer were signifieantly lower in combination group than in control group. Conclusion： Compound radix sophorae flavescentis injection can delay the occurrence of radiation stomatitis and improve the clinical symptoms. This is an effective means of preventing radiation stomatitis.