复方苦参注射液治疗胃肠癌术后化疗患者58例

Effect of matrine injection in 58 gastrointestinal cancer patients with postoperative chemotherapy

目的:观察复方苦参注射液在胃肠癌术后化疗中的作用。方法:应用复方苦参注射液联合FOLFOX方案化疗治疗胃肠癌58例(试验组),与单纯化疗组58例对照。结果:试验组生存质量的改善明显优于对照组(P<0.05);化疗后血白细胞减少、肝功能及神经毒性、恶心呕吐等在试验组与对照组比较有统计学意义(P<0.05)。结论:复方苦参注射液联合化疗辅助治疗胃肠癌,能明显减轻化疗的不良反应,提高患者对化疗的耐受性,改善患者的生存质量。

Objective： To observe the effect of compound matrine injection in gastrointestinal cancer patients with postoperative chemotherapy. Methods： Postoperative gastrointestinal cancer patients were treated with either matrine injection combined with FOLFOX chemotherapy （n = 58） or the chemotherapy alone （n = 58, control）. Results： Compared to control group, combination with matrine injection significantly improved the quality of life after chemotherapy in combination group （ P 〈 0. 05 ） , significantly attenuated neutropenia, liver dysfunction, neurotoxicity, nausea and vomiting after chemotherapy （P 〈 0.05 ）. Conclusion： Compound matrine injection combined with chemotherapy as adjuvant treatment can significantly reduce adverse effects of chemotherapy, and improve patient tolerance to chemotherapy and the quality of life in patients with gastrointestinal cancer.