铂类抗肿瘤药物米铂的合成及结构表征

Synthesis and structural characterization of miriplatin,a platinum-based anti-tumor drug

目的:合成抗肿瘤新药米铂。方法:以顺式-(1R,2R)-1,2-环己二胺-二碘合铂(环铂)、硝酸银、正十四碳酸、氢氧化钠为原料合成米铂,采用元素分析、质谱、红外光谱、核磁共振氢谱和热分析对其结构进行表征。结果:合成的化合物结构与标题化合物一致,产率约73%。结论:该方法便于操作,产率高,适合进一步研究。

Objective： To synthesize the platinum-based anti-tumor drug miriplatin. Methods： Miriplatin was prepared from （1R,2R） -1,2-cyclohexanediamine-N, N/ ） platinum （II） diiodide, silver nitrate, myristic acid and sodium hydroxide. The structure was characterized by elemental analysis, ESI-MS, FT-IR, 1H-NMR and thermal analysis. Results： The structure was consistent with the title compound, and the yield was about 73%. Conclusion ： A practical synthesis procedure is developed, which has advantages of easier operation and higher yield ; it is suitable for the further studies of miriplatin.