Hedgehog信号通道与相关干细胞增殖与分化的研究进展

Research development of Hedgehog signal pathway and proliferation and differentiation of related stem cells

背景:Hedgehog蛋白为成形素蛋白,其相关信号通道参与胚胎发育和成体组织再生。目的:对Hedgehog信号通道相关干细胞的增殖及分化研究近况进行综述。方法:应用计算机检索CNKI和PubMed数据库中2000-01/2010-12关于Hedgehog信号通路的文章,在标题和摘要中以"hedgehog信号通道,细胞增殖,细胞分化,信号调控"或"Hedgehog signaling pathway,cell proliferation,cell differentiation,signal pathway controlling"为检索词进行检索,选择关于Hedgehog信号通道对各种干细胞及成体器官作用内容的文章,初检到169篇,根据纳入标准选择27篇进行综述。结果与结论:具有多种分化潜能的干细胞发育成具有特定生物学功能的组织细胞是受到干细胞自身或外在的、近程或远程的信号调控的,其中细胞之间的相互信息传递在细胞发育分化过程中扮演着重要角色。Hedgehog信号通路起到维持细胞增殖、分化、凋亡之间的平衡,其能够调节相邻细胞之间的分子差异,对细胞分化命运起决定性作用。

BACKGROUND：Hedgehog protein is morphogen,and the signal pathway which is related to Hedgehog protein takes part in the embryogenesis and proliferation and differentiation of adult tissues.OBJECTIVE：To review the proliferation and differentiation of stem cells related to Hedgehog signal pathway.METHODS：The articles related to Hedgehog signaling pathway in CNKI database and PubMed Database from January 2000 to December 2010 were retrieved with the key words of ＂Hedgehog signaling pathway,cell proliferation,cell differentiation,signal pathway controlling＂.The articles related to the function of Hedgehog signaling pathway to several kinds of stem cells and adult organs were selected.A total of 169 literatures were obtained from computer screen,and 27 documents of them were involved for summarization according to inclusion criteria.RESULTS AND CONCLUSION：Stem cells with multiple differentiation potential developed into histiocytes with special biological function were regulated by stem cells or external,short-range or long-range signal.Intercellular information transfer plays an important role in the development and differentiation of cells.Hedgehog signal pathway can maintain the balance of cell proliferation,differentiation and apoptosis,and can regulate molecular difference among flanking cells,and play a crucial effect on cell differentiation.