血小板裂解液对脐带间充质干细胞增殖与分化的影响

Platelet lysate on the proliferation and differentiation of umbilical cord mesenchymal stem cells

背景:脐带间充质干细胞是近年来干细胞生物学研究中发现的重要细胞之一,在细胞治疗领域有着良好的应用前景。血小板裂解液对于干细胞的增殖及诱导分化都存在不同程度的有利作用,在一定程度上甚至可以代替甚至优于血清在培养基中的作用。目的:对血小板裂解液结合脐带间充质干细胞的研究作一综述。方法:于万方等中文数据库和PubMed等英文数据库中,以"脐带,间充质干细胞,血小板裂解液,分化,增殖"为关键词检索文献,总结脐带间充质干细胞及血小板裂解液的生物学特性和相关临床应用,并汇总有关血小板裂解液对脐带间充质干细胞增殖活性和诱导分化能力影响的研究结果。结果与结论:血小板裂解液对脐带间充质干细胞的增殖活性及诱导分化有正面影响,这使血小板裂解液在干细胞移植治疗中将会起到无可比拟的作用。

BACKGROUND：In recent years,umbilical cord mesenchymal stem cells（UCMSCs） are one of significant cells in stem cell biology.UCMSCs have a good prospect in the field of cell therapy.Platelet lysate has varying degrees of beneficial effect for proliferation and differentiation of stem cells.To a certain extent,it can replace or even is better than the serum in the culture medium.OBJECTIVE：To summarize the studies regarding platelet lysate combined with UCMSCs.METHODS：Literatures can be searched with keywords like umbilical cord,mesenchymal stem cells,platelet lysate,proliferation and differentiation in Chinese databases such as Wanfang and English databases such as PubMed.The biological characteristics and clinical practice of UCMSCs and platelet lysate were summarized.Studies regarding the effect of platelet lysate on the proliferation and differentiation of UCMSCs were included.RESULTS AND CONCLUSION：Platelet lysate plays a positive role on the proliferation and differentiation of UCMSCs,thus indicating a significant role in the stem cell transplantation.