摘要
肝脏缺血再灌注损伤是肝脏外科中常见的病理生理现象,微循环障碍、氧自由基过多及细胞凋亡等是引起损伤的重要机制,而研究发现热休克蛋白、一氧化氮、内皮素、血红素氧化酶、某些细胞因子及基因有保护肝脏、降低肝脏缺血再灌注损伤的作用,进一步研究其保护机制,对研究肝脏疾病有重要的临床意义。
Hepatic ischemia-reperfusion injury is a common pathophysiological phenomenon in liver surgery, that caused by microcirculatorydisturbance, oxygen free radicals, apoptosis, and so on. Study found that heat shock protein, nitric oxide, endothelins, heme oxygenase, some cytokines and genes can protect the liver and reduce hepatic ischemia-reperfusion injury. It has important clinical significance in hepatic disease, so to further study the defense mechanism of hepatic ischemia-reperfusion injury.
出处
《中国现代医生》
2011年第25期28-30,33,共4页
China Modern Doctor
关键词
肝脏
缺血再灌注损伤
保护机制
Hepar
Ischemia-reperfusion injury
Defense mechanism
