中西医结合治疗脑梗死后癫痫的初步观察

Initial observation on treating epilepsy after cerebral infarction in the integrative medicine

目的:中药可减少丙戊酸钠的用量,减轻其毒副作用,延缓脑梗死后癫痫的病情进展,并可提高脑梗死的治疗效果。方法:采用随机双盲安慰剂对照试验设计方法,选择60例癫痫患者,中医辨证证型均为癖阻脑络型患者,分为西药对照组、西药+中药组,分别服用,疗程52周。观察:①中医证侯疗效;②对患者发作次数的影响;③安全性观察。结果:①患者发作次数减少:治疗组和对照组总有效率分别为85.9%和63.1%,两组比较有统计学意义(P<0.05)。②中医证候疗效:治疗组和对照组总有效率分别为89.7%(26/29)和71.4%(20/28),两组比较有统计学意义(P<0.05)。③安全性观察:治疗组和对照组无明显不良反应。结论:活血安痫丸可以提高脑梗塞后癫痫的治疗效果,具有明显疗效和良好的安全性。

Objective： TCM can reduce the using amount of sodium valproate, ease its toxic side effects, defer the progression of epilepsy after stroke, and then improve the treatment effects with cerebral infarction. Methods： Applying randomized double-blind placebo-controlled trial design method, selected 60 cases of epilepsy patients, TCM syndrome differentiation was also network-type resistance brain addiction patients, which divided into western medicine control group and western medicine plus TCM group, respectively taked, 52 weeks as a course. Observation： First, syndrome effect of TCM; Second, affecting patients incidence of disease; Third, safety observation. Results： First, patients reduced incidence of disease; Treatment group and control group, the total effective rates were 85.9% and 63.1%, the two groups was statistically significant （P〈0.05）. Second, syndrome effect of TCM： Treatment group and control group, the total effective rate was 89.7% （26/29） and 71.4% （20/28）, the two groups were statistically significant （P〈0.05）. Third, safety observation： Treatment and control groups weren＇t significant adverse reactions. Conclusion： Huoxue Anxian wan can improve the treatment effects of epilepsy after cerebral infarction, and have significant efficacy and good safety.