苦参素联合还原型谷胱甘肽治疗药物性肝炎疗效评价

Effects evaluation of treating drug-induced hepatitis with matrine plus reduced glutathione

目的:探讨苦参素和还原型谷胱甘肽对药物性肝炎的临床疗效。方法:采用前瞻性研究,对2008年6月～2010年5月诊断为抗结核药物性肝炎160例患者随机分为治疗组80例和对照组80例,治疗组予苦参素和还原型谷胱甘肽治疗,对照组进行常规护肝治疗,治疗4周对疗效进行统计学分析。结果:结核药物性肝炎大多发生于强化期内,治疗组的疗效显著优于对照组(P<0.05)。结论:苦参素和还原型谷胱甘肽治疗可明显改善药物性肝炎表现及恢复肝功能作用,对于结核药物性肝炎有较好疗效,而且临床应用安全。

Objective： To explore the clinical effect of treating drug-induced hepatitis with matrine plus reduced glutathione. Methods： Applying prospective study, 160 patients with anti-TB drug-induced hepatitis were diagnosed in May from June 2008 to May 2010 were randomly divided into treatment group for 80 cases and control group for 80 cases. The former was treated with matrine plus reduced glutathione, while the latter was treated with routine drugs. Both of two groups applying 4 weeks of treatment and statistically analyzed. Results： Mostly tuberculosis drug-induced hepatitis were happened in strengthening period, and effect in treatment were obviously better than control group （P〈0.05）. Conclusion： Matrine plus reduced glutathione could obviously improved the performance of drug-induced hepatitis and restore the role of liver function, which had a good effect in treating tuberculosis drug-induced hepatitis, and it＇s safe in clinical applying.