正交设计法优选复方泽泻滴丸的制备工艺

Preparation technology of compound alisma pills by orthogonal design method

目的:考察复方泽泻滴丸的最佳制备工艺。方法:采用滴制法结合评分法对影响滴丸成型因素进行了考察。从基质、冷却剂的温度、提取物与基质用量的配比以及药液温度等方面用正交实验法进行考核。结果:优选制备工艺条件为:B3A1D1C1,即基质(PEG4000﹕PEG6000=3﹕1),药物与基质(1﹕4),料温为75℃,滴距5～8cm,滴速为45d/min,冷凝剂为液体石蜡,冷凝剂的温度为0～2℃。结论:采用优选制备工艺条件所得复方泽泻滴丸外观质量良好、丸形圆整、色泽均一,证明该工艺稳定可行。

Objective： To establish the best preparation technology process of compound alisma pills. Methods： To investigate the formation factor of pill by the pill making technique and scoring. Evaluating the orthogonal experimental method through matrix, coolant temperature, matrix of drug and dosage, liquid temperature and other parts. Results： The best prescription is B3A1D1C1, matrix （PEG4000 ： PEG6000=3 ： 1）, drag and matrix （1： 4）, material temperature 75℃, the distance of drop is 5-8cm, dropping speed 45 drops/min, refrigerant liquid is paraffin, temperature of refrigerant is 0-2℃. Conclusion： Making compound alisma pills by optimization preparation process is reasonable and feasible.