新型抗高血糖药物探索

An Exploration on the New Anti-hyperglycemic Medicine

随着对糖尿病基础理论研究的深入,具有多种作用机制的新型抗高血糖药物逐步应用于临床。胰高糖素样肽1(GLP-1)类似物及二肽基肽酶Ⅳ(DPPⅣ-)抑制剂都是通过减少GLP-1在体内的降解,从而达到抗高血糖的目的。2型钠葡萄糖转运子抑制剂是通过增加尿中葡萄糖的排泄而控制高血糖。现就这些药物的作用机制及临床评价加以综述。

Along with the further study into the basic theories of diabetes,the anti-hyerglycemic medicine with various mechanisms have been applied in the treatment.Both Glucagon-like peptide-1（GLP-1） analogues and dipeptidyl peptidase Ⅳ（DPP-Ⅳ）inhibitors can decrease the high level of blood glucose by decreasing the degradation of GLP-1 in human body.Sodium-glucose co-transporter 2 inhibitors can also control the high level of blood glucose by increasing the evacuating glucose in urine.Here is to focus on the working mechanism of these medicines and their value in clinic.