一枝黄花总皂苷对家兔心脏和血压的影响

The Effect of Solidago Saponin on the Heart and Blood Pessure in Rcbbits

目的：研究一枝黄花总皂苷对家兔心脏、血压的作用。方法；麻醉鬼进行试验测定其心输出量（CO）、颈动膝压（BP）、颈动脉平均压（MAP）、左心室收缩压（LVSP）和左心宣舒张柬压（LVEDP）。结果：一枝黄花总皂苷的三个剂量组对血压均有明显降低作用（P均〈0．05），高剂量组降压效应强于申剂量组和低剂量组，作用发生快，约1min后血压开始回升，5min后血压接近给药前水平。与生理盐水组比较，一枝黄花总皂苷对心率有显著抑制作用（P〈0．05），且随着剂量的增加，抑制效果加强；一枝黄花总皂苷对家兔CO、MAP、LVSP均显著降低作用（P均〈0．05）；而对LVEDP明显升高（P〈0．05），且随着剂量的增加，效果依次加强。结论：一枝黄花总皂苷具有明显的降压作用和抑制心功能的作用。

Objective： To study the effect of Solidago saponin on the heart and blood pessure in rabbits. Methods： It was tested that the cardiac output（CO）, carotid arterial pressure（BP）, carotid after, mean pressure（MAP）, left ventrieular systolic pressure（LVSP） and left ventricular end diastolic pressure（LVEDP） on the anesthetized rabbits.Results：The BP of three doses of Solidago saponins were significantly lower （P〈O.05）,and the role of lowing BP of high dose group was stronger than the middle dose and low dose group.Solidago saponins has a rapid onset and short duration just for 5min.Compared with the saline group, Solidago saponins could significandy inhibited heart rate （P〈0.05）,and had a dose-effect relationship.Solidago saponins could significantly lower CO, MAP, LVSP （P〈0.05）, while LVEDP was significantly higher （P〈0.05）, and with the dose increased, the effect was strengthened.Conclusion：Solidago saponins had obvious hypotensive effect and inhibition of cardiac function.