摘要
目的：研究骨伤方Ⅰ号对骨折的治疗作用，并对其治疗的机理作初步探讨。方法：消肿和镇痛实验中，按随机数字表法等分4组，空白组、自拟骨伤方Ⅰ号高、中、低剂量组，灌胃给药。采用二甲苯诱发小鼠耳廓肿胀法研究其抗炎作用；采用热板法致小鼠舔后足研究其镇痛作用。在成骨实验中：制作大兔骨折模型，术后次日灌胃给予骨伤方Ⅰ号，分别于给药后14，28d，测定骨折处骨矿物密度，同时测定血小板。结果：骨伤方Ⅰ号组显著降低二甲苯致小鼠耳肿胀的肿胀率，增加小鼠的痛阈值。给药14d、28d后，骨伤方Ⅰ号高、中剂量组的骨密度增加，与空白组比较有显著性差异（P〈0．05）；给药14d、28d后可降低血小板聚集率。结论：自拟骨伤方Ⅰ号具有显著的消肿及镇痛作用，能加快骨矿沉积速率，提高骨密度，改善血液流变学。
Objective：To investigate the therapeutic effect of traumatology＆orthopedicsI on fracture and explore its mechanism.Methods：detumescence and analgesia experiment：The experimental animals which respectively intragastrac administration were divided into normal group, high dose group, middle dose group and low dose group. The methods included hot-plate procedure and the ear swelling induced with xylene.Besides, The bone mineral density （BMD） and the parameters of hemorheology in the fractured radius were also observed in 14 and 28 days after treatment. Results：The traumatology＆orthopedicsI can reduce engorgement and increase the pain threshold. The high and middle dose group can increase the BMD and reduce platelet aggregation, which had obvious variance compared with the control group （ P〈0.05 ） . Conclusion： The traumatology＆orthopedicsI have the effect of detumescence and analgesia,can improve and accelerate fracture healing in the catagmmic rabbits by increasing BMD and improving blood theology.
关键词
自拟骨伤方Ⅰ号
消肿
镇痛
骨折
骨密度
Traumatology＆orthopedicsI
detumescence
analgesia
facture
Bone mineral density
