蛞蝓冻干粉对支气管哮喘的治疗作用

Effect of Limax Lyophilized Powder on Bronchial Asthma

目的:研究蛞蝓冻干粉对支气管哮喘的治疗作用。方法:运用氢氧化铝加卵白蛋白建立豚鼠支气管哮喘模型,观察蛞蝓冻干粉对支气管哮喘的治疗作用及对卵蛋白致敏豚鼠肺支气管灌流量、肺泡灌流液和血清中炎症因子的影响。结果:蛞蝓冻干粉能减少诱发豚鼠哮喘的死亡数,延长诱喘潜伏期(P<0.05),其抗哮喘作用与对照药氨茶碱相当;能显著降低哮喘豚鼠的外周血和肺泡灌洗液的白细胞计数以及肺组织嗜酸性粒细胞浸润(P<0.05),且在中剂量63 mg/kg时,药物达到最佳效应;氨茶碱和蛞蝓冻干粉中、高剂量治疗组豚鼠肺支气管灌流量显著增加,血清和肺泡灌洗液(BALF)中IL-2和IL-4显著降低(P<0.05)。结论:蛞蝓冻干粉能显著抑制支气管哮喘的发生。

Objective：To study the effect of Limax lyophilized powder on bronchial asthma.Methods：The allergic asthma model was established in guinea pigs by combined utilization of aluminum hydroxide and egg albumin to investigate the effect of Limax lyophilized powder on the bronchial flow and on the level of inflammator in bronchoalveolar lavage and serum.Results：The mortality of asthma laboratory guinea pigs was reduced and the incubation period of asthma was extended significantly in Limax lyophilized powder groups.Its antiasthmatic effect was as efficient as the control drug（aminophylline）.The leucocyte count was decreased in peripheral blood and the bronchoalveolar lavage fluid.The infiltration of pulmonary tissues eosinophil was also significantly reduced.Further more,the most efficient effects was showed in Limax lyophilized powder at the moderate dosage（63mg/kg）.The bronchial perfusion flow was increased and the level of IL-2 and IL-4 in blood serum and bronchoalveolar lavage fluid was decreased obviously in the aminophylline group and Limax lyophilized powder groups at moderate and high dosage.Conclusion：Limax lyophilized powder could inhibit bronchial asthma evidently.