NB-UVB对急性寻常型白癜风患者血清ICAM-1表达的影响

Effect of NB-UVB on ICAM-1 expression of acute ordinary vitiligo patients

目的:探讨窄谱中波紫外线(NB-UVB)对急性寻常型白癜风患者血清细胞间黏附分子-1(ICAM-1)表达的影响及其作用机制。方法:急性寻常型白癜风患者38例作为观察组,采用NB-UVB进行治疗,另选择健康体检者20例作为对照组,采用酶联免疫吸附法测定白癜风患者治疗前、后和健康体检者血清中ICAM-1水平。结果:观察组治疗后ICAM-1水平较治疗前明显降低,差异有统计学意义(P<0.01),接近正常值,与对照组比较,无明显差异(P>0.05)。结论:NB-UVB对急性寻常型白癜风患者作用机制可能是产生对抗ICAM-1的因子,从而达到治疗作用。

Objective To explore effect of NB-UVB on ICAM-1 expression of acute ordinary vitiligo patients. Methods： A total of 38 cases with acute ordinary vitiligo were treated by NB-UVB. ICAM-1 level was determined by radioimmunity assay. Results. There was significant difference in ICAM-1 be- tween vitiligo patients and healthy persons before treatment （P〈20.01）. There was significant difference after treatment（P〈0.01）. And there was no significant difference between vitiligo patients and healthy persons after treatment （P〈0.05）. Conclusions. NB-UVB may produce anti-ICAM-1 factors to treat acute ordinary vitiligo.