摘要
目的探讨胸乳路径腔镜甲状腺手术对机体的创伤性。方法将2009年1月至2010年12月收治的60例甲状腺良性肿瘤依据患者意愿分成腔镜手术组(A组=32例)及传统手术组(B组=28例),分别比较术后2h、1d和3d3个时点外周血白细胞介素.2(IL)·2、IL-6、C·反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)检测值。结果腔镜组术后3个对应时点血清IL-2值[(12.6±2.1)、(11.8±1.9)、(11.8±3.0)ng/L]、CRP值[(1.6±0.7)、(2.4±0.9)、(2.5±0.9)mg/L]、TNF-α值[(53.2±6.8)、(49.1±5.5)、(46.5±5.0)ng/L]与传统组术后相对应3个时点血清IL-2值[(10.6±1.1)、(11.2±2.6)、(12.0±3.2)ng/L]、CRP值[(0.8±0.6)、(2.4±0.5)、(2.4±0.7)mg/L]、TNF-α值[(48.5±7.1)、(51.3±6.2)、(41.5±13.7)ng/L]组间差异无统计学意义(P值均〉0.05);腔镜组术后3个对应时点血清IL-6值[(4.8±2.4)、(4.3±2.1)、(5.4±5.6)ng/L]与传统手术组术后相对应时段血清IL-6值[(6.4±2.4)、(7.1±4.1)、(4.9±0.8)ng/L]组间术后2h、1d差异有统计学意义(P〈0.05)。结论腔镜甲状腺手术对机体的创伤与传统甲状腺手术比较属相对微创,在不给机体带来更大创伤同时,可获得美容效果,是一种值得推广的术式。
Objective To explore the injury of endoscopic thyroidectomy via breast areola approach and the anterior chest wall to human body. Methods Sixty patients with thyroid benign tumor, hos- pitalized from Janurary 2009 to December 2010, were divided into endoscopic thyroidectomy group and traditional thyroid surgery group with respect of the patients' own willing. The levels of interleukin (IL)-2, IL-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-α in the blood were determined 2 h, 1 day and 3 days after surgery. Results No statistically significant difference was found between the 2 groups in the levels of IL-2 [ endoscopic group: ( 12. 6 ± 2. 1 ), ( 11.8 ± 1.9), ( 11.8 ± 3.0) ng/L; traditional group: (10.6 ±1.1), (11.2 ±2.6), (12.0 ±3.2) ng/L], CRP [endoscopic group: (1.6 ±0.7), (2.4±0.9), (2.5±0.9) mg/L; traditional group: (0.8±0.6), (2.4±0.5), (2.4±0.7) mg/L], TNF-ct [ endoscopic group : ( 53.2 ± 6. 8 ), ( 49. 1 ± 5.5 ), (46. 5± 5.0 ) ng/L ; traditional group (48. 5 ±7.1 ), (51.3 ±6.2), (41.5 ± 13.7) ng/L] at different time points. The levels of IL-6 showed signifi- cant difference between two groups at 2nd h and first day after surgery ( P 〈 0. 05 ) [ endoscopic group : (4. 8 ±2. 4), (4. 3 ±2. 1 ), (5.4 ±5.6) ng/L; traditional group: (6.4 ±2.4), (7.1 ±4. 1 ), (4. 9 ± 0. 8 ) ng/L]. Conclusion Compared with traditional surgery, endoscopic thyroidectomy is relatively minimally invasive and worthy of being widely applied for its preservation of the outlook of patients and not increasing the injury to patients.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2011年第9期1571-1573,共3页
Chinese Journal of Experimental Surgery
基金
乌鲁木齐市科学技术计划资助项目(Y09231001)