系统性红斑狼疮微循环下的中医分型与免疫指标和狼疮活动相关性的研究

Syndrome Differentiation of Chinese Medicine with Microcirculation of Tongue and Its Relation with Disease Immune Indexes and Activity in Systemic Lupus Erythematosus

目的:探讨系统性红斑狼疮舌质微循环下的中医客观辩证与免疫指标和疾病活动的相关性。方法:符合SLE诊断标准的患者46例次,通过微循环观察,根据舌尖微循环将SLE分为血虚型和瘀热型。常规检测抗核抗体(ANA)、抗双链DNA(ds-DNA)和抗Smith(Sm)抗体。根据SLE活动指数标准分为活动组和非活动组。结果:瘀热型主要见于SLE疾病的活动期,与SLE的相关抗体有明显的相关性;血虚型主要见于稳定期。结论:瘀热型与狼疮活动期有明显的相关性。

This study aimed to investigate syndrome differentiation of Chinese medicine with the microcirculation of tongue in systemic lupus erythematosus （SLE） patients, and to explore its relation with disease active stage and immune indexes. Microcirculation microscope was used in the detection of microcirculation of tongue tip feature among forty-six SLE patients. According to microcirculation of tongue, patients were divided into two types, which are the blood deficiency type and blood stasis-heat type. The ANA, ds-DNA and anti-smith antibody of SLE patients were detected by routine methods. The active and inactive phases were divided according to diseases activity index （SLEDAI） in SLE patients. The results showed that blood stasis-heat type was mostly observed in the active phase; and blood deficiency type was detected in inactive phase. It is concluded that blood stasis-heat type had significantly correlation with the activity in SLE.