期刊文献+

中药方剂创新研究的启示与思考——从《科学转化医学》首次发表中医方剂研究论文谈起 被引量:2

Reflection on Chinese Medicine Formula Innovative Studies-Comment on the First Publication of Chinese Medicine Formula in Science Translational Medicine
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摘要 2010年《科学转化医学》杂志首次发表了耶鲁大学研究人员关于中药古方黄芩汤来源的实验室配方PHY906用于减轻化疗药物伊立替康胃肠道副作用的论文。该研究对于中药尤其是方剂的创新研究提供了新的研究模式和经验借鉴。笔者试图就该研究对未来中药(方剂)研究的意义与启示做一点粗浅的探讨。 In the latest issue of Science Translational Medicine, a study was published related to the beneficial effect of a modern laboratory formula derived from an ancient Chinese medicine formula termed Huangqin Tang in reducing the gastrointestinal toxic effects of irinotecan in chemotherapy. This study was performed by researchers from Yale University. It provides new research models and experiences for Chinese medicine formula investigation and development. In this commentary, the authors discussed the inspirational significance of this report.
出处 《世界科学技术-中医药现代化》 2011年第4期704-706,共3页 Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金 澳门特别行政区科学技术发展基金(029/2007/A2):中药抗肿瘤的系统药理学评价与药效物质研究 负责人:王一涛 澳门大学研究基金(SRG013-ICMS11-CXP):The hepatoprotective effect of germacrone curdione and cucurbitacin B in vitro 负责人:陈修平
关键词 中药复方 创新 黄芩汤 Chinese medicine formula, innovation, Huangqin Tang
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  • 1Hard to swallow. Nature, 2007, 448(7150):105-106.
  • 2Ye M, Liu SH, Jiang Z, et al. Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer thera- py. Rapid Commun Mass Spectrom, 2007, 21(22):3593-3607.
  • 3Wang L, Zhou GB, Liu P, et al. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci USA, 2008, 105(12):4826- 4831.
  • 4Yen Y, So S, Rose M, et al. Phase I/II study of PHY906/capecitabine in advanced hepatocellular carcinoma. Anticancer Res, 2009, 29 (10): 4083-4092.
  • 5Eng C. Are herbal medicines ripe for the cancer clinic? Sci Transl Med, 2010, 2(45):45-41.
  • 6Farrell MP, Kummar S. Phase I/IIA randomized study of PHY906, a novel herbal agent, as a modulator of chemotherapy in patients with ad- vanced colorectal cancer. Clin Colorectal Cancer, 2003, 2(4):253-256.
  • 7Tilton R, Paiva AA, Guan JQ, et al. A comprehensive platform for qual- ity control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906. Chin Med, 2010, 20(5):30.
  • 8Lam W, Bussom S, Guan F, et al. The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity. Sci Transl Med, 2010, 18 (45):45-59.
  • 9张保国,梁晓夏,刘庆芳.黄芩汤现代药效学研究与临床运用[J].中国中药杂志,2008,33(22):2587-2590. 被引量:23

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