胸腺肽α1对结直肠癌患者化疗期间细胞免疫功能的影响

Effect of thymosin α1 on cellular immunologic function of patients with colorectal carcinoma during chemotherapy

目的观察胸腺肽α1对结直肠癌患者化疗期间细胞免疫功能的影响。方法将同期行FOLFOX-4方案化疗的74例结直肠癌患者随机分为实验组和对照组,实验组在化疗期间同时予胸腺肽α1皮下注射。化疗开始前及四周期化疗结束后测定两组T细胞亚群、NK细胞活性变化。结果实验组治疗后CD3+、CD4+、CD4+/CD8+、NK细胞活性明显高于治疗前(P<0.05);而对照组变化趋势则与之相反(P<0.05);同时实验组治疗后CD3+、CD4+、CD4+/CD8+、NK细胞活性明显高于对照组(P<0.01)。结论胸腺肽α1可改善结直肠癌患者化疗期间的细胞免疫功能,有利于增强机体的抗肿瘤效应。

Objective To observe the immunomodulatory efficacy of thymosin alpha1 in patients with colorectal carcinoma during chemotherapy.Methods Seventy-four patients with colorectal carcinoma were randomized into experimental group（received thymosin alpha1 1.6 mg three times weekly during chemotherapy with FOLFOX-4） and control group（only receiving chemotherapy with FOLFOX-4）.The peripheral blood T cell subsets and natural killer（NK） activity of patients in both groups were measured before and after treatment.Results The blood levels of CD3＋,CD4＋,CD4＋/CD8＋,NK cell activity in the experimental group were significantly higher after treatment than before treatment（P0.05）,but in the control group,the blood levels of CD3＋,CD4＋,CD4＋/CD8＋,NK cell activity were significantly lower after treatment than before treatment（P0.05）.In the meantime,the levels in the experimental group were significantly higher than those in the control group（P0.01）.Conclusion Thymosin alpha1 can improve the cellular immunologic function of the patients with colorectal carcinoma.