硫酸镁对急性缺血性脑卒中的神经保护作用

The neuroprotective effect of magnesium sulfate in treatment of patients with acute cerebral ischemic stroke

目的探讨硫酸镁对急性缺血性脑卒中患者的神经保护作用。方法采用髓鞘碱性蛋白量化分析方法，分析急性缺血性脑卒中患者硫酸镁治疗前后血清髓鞘碱性蛋白水平变化的幅度，并与对照组对比。结果治疗组20例患者治疗前第1天血清髓鞘碱性蛋白平均水平为（8．3±2．5）μ∥L，治疗后第10天为（4．2±1．7）μg／L；对照组20例患者治疗前第1天血清髓鞘碱性蛋白平均水平为（8．0±3．0）μg／L，治疗后第10天为（6．0±1．4）μg／L。两组患者治疗前后血清髓鞘碱性蛋白水平变化幅度的差异具有统计学意义（t=1．231，P=0．041）。结论硫酸镁可显著降低急性缺血性脑卒中患者血清髓鞘碱性蛋白的水平，具有神经保护作用。

Objective To explore the neuroprotective effect of magnesium sulfate in tretment of patients with cerebral ischemic stroke. Methods 40 patients with cerebral ischemic stroke were selected and randomly divided into experimental group（20 cases） and control group （20 cases）. Among those two groups, the magnesium sulfate therapeutic measure was carried out in the exPerimental group and the control group was treated without magnesium sulfate. The difference rangeability of level of serum myelin basic protein pre and pro-therapy of both groups was compared. Results For the experimental group,the mean level of serum myelin basic protein in the first day pre-therapy was （ 8.3 ± 2.5）μg/L, and （4.2 ± 1.7 ） μg/Lin 10 days pro-therapy, the csrtrol group was （ 8.0 ± 3.0） μg/L for the first day pre-therapy,and （6.0 ＋ 1.4）μg/L in 10 days pro-therapy. The difference rangeability of level of serum myelin basic protein pre and pro-therapy of both groups had statistical significance, compared with the controlled group,the experimental group had lower level of serum myelin basic protein （ t = 1. 231, P = 0. 041 ）. Conclusion Magnesium sulfate could significantly decrease the serum level of myelin basic protein for patients with cerebral ischemic stroke, which irdicate that the magnesium sulfate should have neuroprotective effect on patients with cerebral ischemic stroke.