丁丙诺啡舌下含片与美沙酮用于海洛因依赖门诊稽延期治疗的对照研究

Control study of buprenorphine sublingual tablets and methadone for heroin addicts on out patients treat- ment during recovery period

目的观察丁丙诺啡舌下含片与美沙酮用于海洛因依赖者稽延期治疗的价值。方法对完成脱毒治疗患者，依先后次序交叉纳入观察组与对照组，分别给予丁丙诺啡舌下含片和美沙酮治疗6个月，观察操守时间，并于人组前后做焦虑量表评分。结果丁丙诺啡舌下含片组比美沙酮组的操守时间长（P〈0．01），焦虑评分低（P〈0．05）。结论丁丙诺啡舌下含片于海洛因依赖门诊稽延期治疗能更好地缓解焦虑情绪并延长操守时间。

Objective To observe the effect of buprenorphine sublingual tablets （Bup） and methadone for heroin addicts on out patients treatment during recovery period. Methods Heroin addicts who completed acute drug detoxification treatment were assigned in the order of cross to the observation group and control group. The observation group and the control group were treated with Bup and methadone, respectively for six months. Both groups were ob- served on the time of keeping heroin abstinence during the treatment and were assessed with Anxiety Scale before and after Bup or methadone treatment. Results Bup group kept abstinence from heroin longer than methadone group （ P 〈 0.01 ）, and had lower anxiety scores （ P 〈 0.05 ）. Conclusion Bupernorphine sublingnal tablets used for out patients at recovery period could better alleviate heroin addicts＇ anxiety and prolong their abstinence time.