血浆胱抑素C浓度与非慢性肾病冠心病患者冠状动脉病变严重程度的相关性

Correlation between Plasma Cystatin C Concentration and the Severity of Coronary Artery Disease in Patients without Chronic Kidney Disease

目的观察胱押素C（cystatinC，CysC）浓度是否能反映非慢性肾病冠心病（coronaryarterydisease，CAD）患者冠状动脉病情严重程度。方法检测106例行冠状动脉造影术患者血浆中CysC及其相关指标的浓度．根据血清肌酐（SCr）浓度估算肾小球滤过率（glomerularfiltrationrate，GFR），以GFR60ml／min·1．73m^2为界值，将患者分成慢性肾病组（chronickidneydisease，CKD）和非慢性肾病组；在非CKD组中，以CysC浓度0．9mg／L为界值，分为正常浓度组和高浓度组，并将检测结果进行比较。结果CKD组患者的CysC浓度以及CAD的发病丰与非CKD组相比有显著性差异（f=6．37，x^2=6．88，P〈0．01）。非CKD组中高CysC浓度组与正常CysC浓度组CAD的发病率差异有统计学意义（r=4．21，P〈0．05）。非CKD组CAD患者病情的严重程度与CysC浓度呈正相关0=0．684，P〈0．01）。结论GFR正常的CAD患者，CysC浓度升高与CAD的病情严重程度相关。对于非CKD的CAD患者来说，CysC很可能是监测CAD病情发展的标志物。

Objective To study the correlation between the concentration of plasma cystatin C （Cys C） and the severity of coronary artery disease （CAD）in patients without chronic kidney disease （CKD）. Methods The plasma Cys C and other indexes of 106 patients who underwent coronary angiography were detected. Glomerular filtration rate （GFR）was calculated by serum creatinlne （SCr）. Based on GFR 60 ml/min ·1.73m^2,the patients,were divided into with and without CKD group. Based on Cys C 0.9 mg/L,the patients of non-CKD group were divided into normal and high level group,and then the results from different group were compared. Results The level of Cys C and the incidence of CAD were significantly different between CKD and non-CKD group （t= 6.37, X^2 = 6. 88 ,P〈 0. 01）. Compared with normal Cys C group, the incidence of CAD were significantly higher than that of increased Cys C group （x^2= 4. 21,P〈0. 05） in non-CKD group. Cys C concentration demonstrated positive correlation with the severity of CAD （r= 0. 684 ,P〈0.01） in non-CKD group. Conclu- sion Among CAD patients with normal plasma GFR,the high level of Cys C corelated with the severity of CAD. Cys C might serve as a marker of CAD severity for the CAD patients of non-CKD.