糖尿病肾病患者铁代谢的研究

Study on Iron Metabolism in Diabetic Nephropathy Patients

目的探讨2型糖尿病肾病（DN）患者血清铗（Fe）、转铁蛋白（TRF）、铁蛋白（SF）和尿转铁蛋白（UTF）的变化与临床意义。方法89例DN患者采用免疫化学发光法测定SF，TRF和UTF，免疫比浊法测定胱押素C（CysC）和尿微量清蛋白（mAlb）及化学法测定血清Fe，并与42例2型糖尿病非肾病患者和55倒健康体检者比较。结果2型糖尿病伴肾病组血清Fe，SF，TRF，CysC，UTF和mAlb均显著高于非肾病组和健康对照组（P〈0．01）IDN患者组血清Fe，SF，TRF，UTF与CysC和mAlb呈正相关（P〈0．01）。结论DN患者体内存在以血清Fe，TRF和SF增高为主的铁超负荷，血清Fe，SF，TRF和UTF可作为糖尿病肾损害的早期监测指标。

Objective To investigate the change and the clinical significance of serum iron （Fe）,tranferrin （TRF）,serum ferritin （SF） and uric tranferrin in type 2 diabetes nephrosis （DN） patients. Methods Serum Fe,SF,TRF,UTF,CysC and mAlb were detected in 89 patients with diabetic nephropathy,and compared with 42 type 2 diabetic mellitus without nephropathy and 55 normal controls. Results Serum Fe,SF,TRF,UTF,CysC and mAlb in type 2 diabetes nephrosis patients were significantly higher than those of type 2 diabetic mellitus without nephropathy grop and normal controls. Serum Fe,SF,TRF and UTF were significant correlatted to CysC and mAlb in diabetic nephropathy. Conclusion These results indicated that there existed iron,transferrin and ferritin increased iron overload in diabetic nephropathy,Fe,SF,TRF and UTF may be as diabetic kidney damage monitoring indicators.