中国丙型肝炎血清流行病学研究

A sero-epidemiological study on hepatitis C in China

目的了解中国现阶段丙型肝炎病毒（HCV）感染现状。方法利用中国疾病预防控制中心“2006年中国乙型病毒性肝炎血清流行病学调查”保留的血清，以美国Murex3．0和Ortho3．0抗一HCV试剂为金标准建立标准血清库，筛选中国抗一HCV检测试剂，并用ChironHCVRIBA3．0复核检测结果。结果中国1～59岁人群抗-HCV调整流行率为0．43％（95％CI：0．33％～0．53％），男性和女性抗-HCV流行率分别为O．46％和0．40％，城市和农村人群经调整后均为0．43％。东、中和西部地区人群抗-HCV流行率分别为0．37％（95％CI：0．21％～O．53％）、0．67％（95％C／：0．40％～0．94％）和0．31％（95％CI：0．20％～0．42％），3个地区人群抗-HCV流行率的差异无统计学意义；南方和北方地区人群抗-HCV流行率分别为0．29％（95％CI：0．21％～0．52％）和0．53％（95％CI：0．38％-0．64％）。结论经综合性防治，目前中国属丙型肝炎低流行区。

Objective To better understand and measure the status of hepatitis C virus （HCV） infection, we conducted a sero-epidemiological study using the remaining blood samples and data of the nationwide survey of hepatitis B in Chinese residents which was carried out in 2006. Methods The anti-HCV reagent was screened out from the reagents by the HCV infection blood serum plate with anti-HCV positives or negatives. This plate recognized the Murex 3.0 and Ortho 3.0 reagents as gold standards. Anti-HCV in the blood samples were tested using this reagent and confirmed by Chiron HCV RIBA 3.0 reagents. Results Among the population aged 1 year to 59 year-olds, the overall prevalence rate of anti-HCV was 0.43% （95%CI： 0.33%-0.53%）, with the rates of anti-HCV among males and females as 0.46% and 0.40%, respectively. The prevalence rate of anti-HCV in urban area was 0.43%, and in rural area it was 0.43%. The prevalence rate of anti-HCV in the Eastern, Middle and Western areas were 0.37% （95% （21： 0.21%-0.53% ） , 0.67% （95% CI： 0.40%-0.94% ） and 0.31% （95% CI： 0.20%-0.42% ） respectively. The prevalence rates of anti-HCV for the three areas did not show significant differences, statistically. The prevalence rate of anti-HCV in the South and North areas were 0.29%（95%CI：0.21%-0.52%） and 0.53% （95%CI： 0.38%-0.64%） respectively. Conclusion Our data revealed that China was in the low prevalence area for hepatitis C infection and the results also suggested that the comprehensive measures for HCV control and prevention had been successfully achieved in the country.