奥曲肽联合奥美拉唑治疗上消化道出血的疗效观察

Efficacy Observation of Octreotide Combined with Omeprazole in the Treatment of Upper Gastrointestinal Bleeding

目的:观察奥曲肽联合奥美拉唑治疗上消化道出血的临床疗效。方法:将我院收治的68例上消化道出血患者随机分为2组,观察组(32例)应用奥曲肽联合奥美拉唑治疗,对照组(36例)单独使用奥美拉唑治疗,观察2组患者止血率、平均止血时间和48h内再出血率。结果:观察组48h止血率为90.6%(29/32),对照组48h止血率为77.8%(28/36),2组比较差异有统计学意义(P<0.01)。观察组患者平均止血时间为(21.42±4.21)h,对照组患者平均止血时间为(28.16±5.62)h,2组比较差异有统计学意义(P<0.05)。观察组患者48h内再出血率为3.13%,对照组为22.22%,2组比较差异有统计学意义(P<0.01)。结论:奥曲肽联合奥美拉唑治疗上消化道出血可以缩短止血时间,止血效果好。

OBJECTIVE：To observe clinical efficacy of octreotide combined with omeprazole for upper gastrointestinal bleeding.METHODS：68 patients with upper gastrointestinal bleeding were randomly divided into 2 groups.Observation group（32 cases） was given octreotide combined with omeprazole treatment,and control group（36 cases） was given omeprazole alone.The hemostatic rate,average hemostatic time and rebleeding rate within 48 h were observed.RESULTS：The 48 h effective hemostatic rate of observation group was 90.6%（29/32）,that of control group was 77.8%（28/36）,there was statistical significance（P0.01）.The average hemostatic time of observation group was（21.42±4.21） h,that of control group was（28.16±5.62） h,there was statistical significance（P0.05）.48 h rebleeding rate of observation group was 3.13%,and that of control group was 22.22%,there was statistical significance（P0.01）.CONCLUSION：Octreotide combined with omeprazole treatment for gastrointestinal hemorrhage can shorten the hemostatic time with sound hemostatic efficacy.