克霉唑联合咪康唑治疗妊娠期念珠菌性阴道炎的疗效观察

Efficacy Observation of Clotrimazole Combined Miconazole to Cure Candida Vaginitis in Pregnancy

目的:观察克霉唑联合咪康唑治疗妊娠期念珠菌性阴道炎的临床疗效及安全性。方法:将我院2008年1月-2010年2月收治的100例妊娠期念珠菌性阴道炎患者,随机1:1分为观察组和对照组。对照组用碱性洗液冲洗外阴后,将克霉唑阴道片500mg置入阴道深部;观察组在对照组基础上给予咪康唑霜涂擦瘙痒处,每天2～3次。2组均7d为1个疗程。治疗后第1、4周复查疗效,比较2组患者的治疗有效率、复发率和症状改善率。结果:观察组总有效率为96.0%,复发率为6.0%;对照组总有效率为82.0%,复发率为24.0%。2组总有效率、复发率比较,差异均具有统计学意义(P<0.05)。观察组症状改善率分别为96.0%、88.4%、95.0%;对照组症状改善率分别为82.0%、68.2%、75.6%,2组比较差异有统计学意义(P<0.05)。随访至分娩,均未发生孕产妇感染、早产、新生儿畸形。结论:克霉唑联合咪康唑治疗妊娠期念珠菌性阴道炎安全有效,复发率低。

OBJECTIVE：To observe the clinical efficacy of clotrimazole combined miconazole to treat with candida vaginitis in pregnancy.METHODS：100 patients with candida vaginitis in pregnancy were randomly divided into control group and observation group from Jan.2008-Feb.2010 in our hospital,and 50 cases were in each group.The control group was given alkaline lotion to wash vulva and put the 500 mg of clotrimazole in the deep of vaginal;the observation group was given miconazole cream to erase itching 2～3 times a day.One course of treatment of 2 groups was 7 d.In the first and fourth week,the efficacy was examined,and the clinical efficacy and symptom improvement rate were compared.RESULTS：The total effective rate was 96.0% and the recurrence rate was 6.0% in the observation group;the total effective rate was 82.0% and the recurrence rate was 24.0% in the control group.There were statistically significant differences in the total effective rate and recurrence rate between 2 groups（P0.05）.The symptom improvement rate of the observation group were 96.0%,88.4% and 95.0% while the control group were 82.0%,68.2% and 75.6%.There was significant difference between 2 groups in symptom improvement rate（P0.05）.Followed up to the delivery,there were no occurrences of maternal infection,premature birth,neonatal malformations.CONCLUSION：The clotrimazole combined miconazole to treat with vaginitis in pregnancy is safe and effective,and the recurrence rate is low.