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自身抗原在动脉粥样硬化形成中作用的研究进展 被引量：4

Research progress on the function of autoantigens in atherogenesis
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摘要 动脉粥样硬化（As）是一种由免疫介导的、多因素参与的炎症性疾病。流行病学调查显示，在一些自身免疫性疾病中AS有所加剧，例如系统性红斑狼疮（SLE）和抗磷脂综合征。通过研究认为，几个潜在的自身抗原，如氧化低密度脂蛋白、热休克蛋白65／60和B2糖蛋白I在As的发生和发展中发挥着重要作用。这些新的认识，为人们找到了预防和治疗AS的新靶点。 Atherosclerosis （AS）, a muhifactorial inflammatory disease, has been considered as an im- mune-mediated process. Immune system has been recognized as an important eausitive component of atherosclerotic inflammation. Epidemiological studies demonstrated that atherosclerosis was accelerated in several autoimmune and rheumatic diseases, such as systemic lupus erythematosus （SLE） and antiphospholipid syndrome （APS）. Studies showed several potential autoantigens, such as oxLDL, HSP65/60 and β2-GPI, are important in the patbogenesis of atherosclerosis. These studies many contribute to the development of new approaches in the prevention and treatment of atherosclerosis.
作者 孙喜娟 关秀茹
机构地区 医科大学附属第一医院检验科
出处 《国际免疫学杂志》 CAS 北大核心 2011年第5期260-263,共4页 International Journal of Immunology
基金 黑龙江省自然科学基金资助项目（D200968）
关键词 动脉粥样硬化 自身抗原 氧化低密度脂蛋白 热休克蛋白65/60 Β2糖蛋白I Atherosclerosis Autoantigen OxLDL HSP65/60 β2GPI
分类号 R54 [医药卫生—心血管疾病]
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参考文献27

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二级参考文献21

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同被引文献110

  • 1陈惠萍,胡峰.抗磷脂综合征肾损害[J].肾脏病与透析肾移植杂志,2004,13(5):490-492. 被引量：3
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引证文献4

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国际免疫学杂志
2011年 第5期

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