微囊化法制备润肠片及其药效学实验研究

Preparation of Runchang Tablet by Microencapsulation and Experiment Study on Its Pharmacodynamics

目的研究润肠片的制备工艺及其润肠通便功效。方法用微囊化法制备润肠片,考察制剂的形态、片重差异、崩解时限。用肠水分实验、小肠推进实验、排便实验研究了润肠片对在体小鼠肠功能的影响,探讨了润肠片的药理作用。结果所制制剂为淡黄色片剂,检查符合2010年版中国药典中相关规定。润肠片4g.kg-1能极显著增加小鼠肠水分、小肠推进率和排便数(P<0.01),并且作用强于润肠丸(P<0.05)。润肠片2g.kg-1能极显著增加小鼠肠水分与小肠推进率(P<0.01),显著增加小鼠排便数(P<0.05),并且增加肠水分与小肠推进率的作用强于润肠丸(P<0.05)。结论润肠片具有较润肠丸更显著的润肠通便功效,说明本文设计的润肠片的制备工艺合理、有效。

Objective To study the preparation of Runchang tablet and its effects on lubricating intestine and facilitating bowel movements.Methods Runchang tablet was made from Runchang pill by the means of Microencapsulation.and it was detected in terms of morphology,tablet weight variation and disintegration.Using the tests of intestine moisture、small intestine driving and bowel movements,the effects of Runchang tablet on the function of intestine of mouse was investigated,and its pharmacological action was discussed.Results Runchang tablet manifested faint yellow tablet and its test was in line with standards specified Chinese pharmacopeia（2010 edition）.Runchang tablet（4g·kg-1） could obviously facilitate the intestine moisture、small intestine driving and bowel movements of mouse（P0.01）,and its pharmacological action was superior to that of Runchang pill（P0.05）.It（2g·kg-1）could enforce the intestine moisture and small intestine driving of mouse distinctly（P0.01）,and this action was also superior to that of Runchang pill（P0.05）,of course,it could apparently increase bowel movements of mouse,too（P0.05）.Conclusion The pharmacological action of Runchang tablet is superior to that of Runchang pill.This shows that the preparation of Runchang tablet designed by this paper is correct,effectual,and controllable in quality.