清热利湿中药对肥胖2型糖尿病患者胰岛素抵抗的影响

Study on the effect of Qingre-Lishi Recipe on insulin resistance in patients with obese type 2diabetes

目的观察清热利湿中药对肥胖2型糖尿病患者胰岛素抵抗（insulin resistance，IR）的影响。方法采用随机数字表法将60例患者随机分为两组各30例，对照组采用西医常规降糖治疗，治疗组在对照组治疗基础上给予清热利湿中药，1剂／d，分早晚2次温服。疗程均为8周。疗程结束时比较两组患者中医证候积分变化及空腹血糖（FBG）、餐后2小时血糖（2hPG）、糖化血红蛋白（HbAlc）、空腹胰岛素（FINS）、胰岛素敏感指数（IAI）、血清总胆固醇（TC）、甘油三脂（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）等指标。结果治疗组患者治疗后中医证候积分（5．34±2．15）分、FBG（6．52±O．45）mmol／L、HbAlc（6．02±0．43）％、FINS（7．52±1．28）μIU／ml、IAI（1．62±0．21）、TG（1．13±0．36）mmol／L、HDL-C（1．69±0．20）mmol／L水平与对照组比较，差异有统计学意义（P〈0．05或P〈0．01）。结论清热利湿中药可改善肥胖2型糖尿病患者胰岛素抵抗及临床症状。

Objeetive To observe the effect of Qingre-Lishi Recipe on insulin resistance in patientswith obese type 2 diabetes. Methods 60 patients of obese type 2 diabetes were randomly divided into two groups, the treatment group （30 patients） and the control group （30 patients）. On the basis of routine treatments that were received by both groups, the treatment group was given Qingre-Lishi Recipe additionally, taking twice a day, one in the morning and the other in night, with the total amount as much as one dose. The course for both treatments is 8 weeks. When the treatments were finished, alleviation of main symptoms of Chinese medicine, the levels of FBG （6.52±0.45） mmol/L, HbAlc （6.02±0.43） %, FINS （7.52± 1.28）μIU/ml, IAI （ 1.62±0.21 ）, TG （1.13±0.36） mmol/L, HDL-C （1.69±0.20） mmol/L of patients in both groups were compared. Results After treatments, the changes in alleviation of main symptoms of Chinese medicine, in the level of FPG HbA 1 c, FINS, IAI, TG and HDL-C between the two groups were of statistical significance, （P〈0.05 or P〈0.01）. Conclusion Qingre-Lishi Recipe has an obvious clinical effect in bettering clinical symptoms and alleviating Insulin Resistance in patients with obese type 2 diabetes.