帕罗西汀联合认知行为疗法治疗抑郁症的临床研究

Clinical Study of Paroxetine with Cognitive-Behavioral Therapy on Depression

目的探讨帕罗西汀联合认知行为疗法治疗抑郁症的临床疗效。方法选取82例抑郁症患者,将其随机分为观察组和对照组,每组各41例。对照组患者每日口服帕罗西汀片20 mg;观察组患者在每日给予帕罗西汀片20 mg的基础上进行认知行为治疗,每次30 m in,每周2次,两组均连续治疗8周。分别于治疗前、治疗第4周末、治疗第8周末采用汉密尔顿抑郁量表(HAMD)评定抑郁症状,比较两组间的差异以及临床疗效。结果两组患者治疗第4周末、第8周末的HAMD评分均较治疗前明显减轻(P<0.05,P<0.01),并且以观察组的下降幅度相对较显著,组间比较,差异具有统计学意义(P<0.05)。观察组的有效率为92.7%,对照组有效率为73.2%,差异有统计学意义(P<0.05)。结论帕罗西汀联合认知行为疗法能有效改善抑郁症患者的抑郁状态,提高疗效。

Objective To observe the clinical effect of paroxetine combined with the cognitive-behavioral therapy on depression.Methods Eighty two patients with depression were randomly divided into observation group and control group（each 41 cases）.The patients in control group received paroxetine 20 mg/d,while the patients in observation group received paroxetine 20 mg/d and the cognitive-behavioral therapy,once every 30 minutes,twice a week.The treatment period of both groups was 8 weeks.Before the treatment and at the end of the 4th,and 8th week after the treatment,the depression symptoms were evaluated by Hamilton Depression Scale（HAMD）,the differences of HAMD and clinical effect among two groups were compared.Results HAMD assessment in both groups at the end of the 4th,and 8th week after the treatment decreased obviously than those before the treatment（P0.05,P0.01）,and HAMD assessment in observation group was significantly lower than that in control group（P0.05）.Effective rate in observation group was 92.7%,and control group was 73.2%,the difference in two groups was significance（P0.05）.Conclusion Paroxetine with cognitive-behavioral therapy can effectively improve depression condition in patient with depression,and enhance the curative effect.