P16和survivin蛋白在口腔扁平苔藓及口腔鳞状细胞癌组织中的表达

The Expressions of P16 and Survivin Protein in Oral Lichen Planus and Oral Squamous Cell Carcinoma

目的探讨P16和survivin蛋白在口腔扁平苔藓(OLP)及口腔鳞状细胞癌(OSCC)组织中的表达意义。方法采用免疫组化S-P法检测正常口腔黏膜、OLP及OSCC组织中P16和survivin蛋白的表达。结果 P16蛋白在正常口腔黏膜、OLP及OSCC组织中的阳性表达率分别为80.00%、52.63%和21.05%(P<0.05);survivin蛋白分别为5.00%、31.58%和57.89%(P<0.05)。结论 P16和survivin蛋白的异常表达与OLP癌变的发生发展有关,两者联合检测有助于早期识别OLP癌变。

Objective To research the expression significance of P16 and survivin protein in Oral lichen planus（OLP） and oral squamous cell carcinoma（OSCC）.Methods The expressions of P16 and survivin protein were detected by immunohistochemistry S-P method in the normal oral mucosa,OLP and OSCC.Results The positive rates of P16 protein in the normal oral mucosa,OLP and OSCC were 80.00%,52.63% and 21.05%（P〈0.05）;the positive rates of survivin protein were 5.00%,31.58% and 57.89%（P〈0.05）.Conclusion The abnormal expressions of P16 and survivin protein are related to the canceration of OLP,and the early detection of them can help to identify the canceration of OLP.