舒芬太尼复合氟比洛芬酯用于开胸手术后镇痛的效果

The Analgesic Effect of Sulfentanyl Combined with Flurbiprofen Axetil in the Treatment of Patients with Undergoing Chest Surgery

目的观察舒芬太尼复合氟比洛芬酯用于开胸手术后镇痛的效果。方法将择期行开胸手术患者75例随机均分为A、B、C组,各组于手术结束前30 min静脉给予氟比洛芬酯100 mg,术后48 h行患者静脉自控镇痛(PCIA),A组PCIA配方为舒芬太尼100μg加氟比洛芬酯150 mg,B组为芬太尼0.5～0.6 mg加氟比洛芬酯150 mg,C组为芬太尼0.8～1.0 mg。记录术后0、4、8、24 h疼痛视觉模拟评分(VAS)、镇静评分,同时记录术后24 h PCIA按压次数及毒副反应。结果 3组患者术后SBP、DBP、HR、SpO2、VAS、镇静评分、PCIA按压次数比较差异均无统计学意义(P>0.05)。术后24 h A、B组恶心、呕吐、嗜睡的患者均少于C组。结论舒芬太尼复合氟比洛芬酯用于开胸手术后镇痛效果好,毒副反应轻。

Objective To investigate the analgesic effect of sulfentanyl combined with flurbiprofen axetil in the treatment of patients with undergoing chest surgery.Methods Seventy-five patients scheduled for chest surgery were randomly divided into three groups.All the patients were injected intravenously flurbiprofen axetil 100 mg at 30 min before the end of surgery.Patient-controlled intravenous analgesia（PCIA） was given sulfentanyl 100 μg and flurbiprofen axetil 150 mg in the group A,and fentanyl 0.5-0.6 mg and flurbiprofen axetil 150 mg in the group B,and fentanyl 0.8-1.0 mg in the group C.The visual analogue scale（VAS） scores and the sedation scores at 0,4,8,24 h after surgery,pressing times and toxicities were recorded.Results There were no differences among the three groups in the SBP,DBP,HR,SpO2,VAS scores,sedation scores and pressing times（P〉0.05）.The incidences of nausea,vomiting and somnolence in the group A and in the group B were less than those in the group C.Conclusion Sulfentanyl combined with flurbiprofen axetil offers favorable analgesic effect on the patients with undergoing chest surgery,and the toxicities are light.