复方苦参注射液联合化疗治疗晚期大肠癌的临床效果

Clinical study on treating advanced colorectal cancer with compound Kushen injection plus chemotherapy

目的研究复方苦参注射液联合化疗治疗晚期大肠癌的临床疗效。方法将2006年6月-2009年1月商丘市第一人民医院104例均经细胞学或组织学证实为晚期大肠癌患者随机分为治疗组(复方苦参注射液联合化疗组)和对照组(单纯化疗组),其中治疗组56例,对照组48例,比较两组在疗效、生活质量、不良反应等方面的差异。结果治疗组有效率(CR+PR)为72%,对照组有效率(CR+PR)为65%,比较差异无统计学意义(P>0.05),两组治疗后生活质量改善比较,治疗组有效率为75%(42/56),对照组有效率45.8%(22/48),治疗组患者生活质量改善情况优于对照组,差异有统计学意义(P<0.01),治疗组与对照组主要不良反应比较,白细胞的减少、腹泻、周围神经毒性、恶心、呕吐、贫血、血小板减少发生率比较对治疗组低于对照组,差异有统计学意义(P<0.05)。结论复方苦参注射液可以有效地提高生活质量,减轻化疗不良反应。

Objective To study the clinical effects of treating advanced colorectal cancer with compound Kushen injection plus chemotherapy.Methods Totally 104 cases of patients who were confirmed as advanced colorectal cancer by cytology or histological were randomly divided into the treatment group（compound Kushen combined group） and the control group（chemotherapy alone） in June 2006 to January 2009,56 cases in the treatment group,48 cases in the control group,compared the difference of effect,quality of life,adverse effects.Results The effective rate of treatment group was 72%,in the control group the effective rate was 65%,so the difference was no statistically significant（P0.05）.Quality of life improved after treatment,the effective rate of treatment group was 75%（42/56）,the control group was 45.8%（22/48）,the quality of life of the treatment group was better than the control group,the difference had significance（P0.01）.The effective rate of reduction of white blood cells,diarrhea,peripheral neuritis,nausea,vomiting,anemia,thrombocytopenia in the treatment group was lower than that of the control group,the difference was statistically significant（P0.05）.Conclusions Compound Kushen injection can improve the quality of life,and reduce adverse effects of chemotherapy.