胃癌中Flt-1、PDGFR、bFGFR的表达与COX-2的相关性

Relationship of Flt-1,PDGFR,bFGFR and COX-2 in gastric cancer

目的探讨血管内皮生长因子受体-1(Flt-1)、血小板衍生生长因子受体(PDGFR)、碱性成纤维生长因子受体(bFGFR)和环氧合酶-2(COX-2)与胃癌生物学行为的关系以及受体与COX-2的相关性。方法选择80例手术切除的胃癌标本为观察组,40例慢性非萎缩性胃炎组织为对照组,应用免疫组织化学方法检测上述组织中Flt-1、PDGFR、bFGFR及COX-2的蛋白表达情况。结果 Flt-1、PDGFR、bFGFR及COX-2在胃癌患者中的阳性率分别为52.5%、48.8%、50.7%和52.5%。对照组的阳性率分别为7.5%、2.5%、5.0%和0%,差异均有统计学意义(P<0.01),它们的表达与肿瘤的分期、浸润、淋巴及血道转移呈正相关(P<0.05),与肿瘤的大小、分化程度无关(P>0.05)。3种受体与COX-2的表达成正相关(P<0.01)。4种指标均阳性和4种指标均阴性者与淋巴结及远处转移差异有统计学意义(P<0.01)。结论胃癌组织中Flt-1、PDGFR、bFGFR和COX-2的阳性表达可作为胃癌生长、转移及预后的重要判定指标,它们在胃癌的发生、浸润、转移中可能存在相互诱导,相互协同或叠加作用。

【Objective】 To investigate the relationship of vascular growth factor receptor-1（Flt-1）,platelet-derived growth factor receptor（PDGFR）,basic fibroblast growth factor receptor（bFGFR） and COX-2 to the clinic-pathological of gastric cancer.And to investigate three growth factor receptor relationship with COX-2.【Methods】 Tissue section from 80 gastric cancer（GC）,40 chronic non-atrophy gastritis tissue were examined by using immunohistochemistry for the expression of angiogenic factor receptor and COX-2.【Results】 The positivity rates of Flt-1,PDGFR,bFGFR,COX-2 were 52.5%,48.8%,50.7%,and 52.5% respectively,were significantly higher than in patients with chronic non-atrophy gastritis tissue（P〈0.05）.The high positive expression of three receptors and COX-2 had significant by positive correlation with stage,regional invasion and lymphatic and blood stream metastasis in GC（P〈0.05）.But has no correlation with the size and differentiation degree（P〈0.05）.There has significantly correlation among the expression of Flt-1,PDGFR,bFGFR.The incidence rates of metastasis Four index positively expressed and four index negative has relationship with lymphatic and blood stream metastasis（P〈0.01）.【Conclusions】 The expression of Flt-1,PDGFR,bFGFR might be significantly correlation with growth,invasion and metastasis of gastric cancer.The four receptors together may play coordination role in angiogenesis,invasion.