多肿瘤标志物联合检测在消化系统肿瘤诊断中的应用评价

Application evaluation of multi-tumor markers combination detection in diagnosis of alimentary system tumor

目的探讨多肿瘤标志物蛋白芯片(简称C12)技术在消化系统肿瘤诊断中的应用价值。方法应用C12检测系统检测90例消化系统肿瘤患者血清中12项肿瘤标志物,包括糖类抗原(CA)125、人绒毛膜促性腺激素(HCG)、CA242、铁蛋白、CA15-3、游离前列腺特异性抗原(Free-PSA)、人生长激素、CA19-9、癌胚抗原(CEA)、甲胎蛋白(AFP)、神经元特异性烯醇化酶、前列腺特异性抗原,分析和比较不同组合肿瘤标志物在诊断中的应用价值。结果 90例消化系统肿瘤患者肿瘤标志物阳性率较高的有CA19-9 66.7%,CA242 55.6%,CA125 50.0%,CEA41.1%,AFP 23.3%,铁蛋白20.0%;CA19-9+CA242+CA125+CEA组合与C12联合检测差异无统计学意义(P<0.05),再增加测试组合并未明显提高检出阳性率。结论 C12对消化系统肿瘤的临床诊断有一定辅助作用,有必要开发和制备具有较强针对性、经济实用的新型多肿瘤标志物蛋白芯片检测系统,以增强其临床实际应用价值。

Objective To evaluate the application value of multi tumor markers protein biochip technology in the diagnosis of alimentary system tumors. Methods 12 kinds of tumor remarks in 90 patients with alimentary sys- tem tumor were detected by means of multi tumor markers detecting system. Meanwhile the diagnostic values of dif- ferent combinations of tumor remarks were analyzed and compared. Results The higher positive rates of tumor re- marks were CA19-9（66.7%）,CA242（55.6%） CA125（50.0%）,CEA（41. 1%）,AFP（23. 3%）,ferritin（20.0%）. There were no statistical difference between CA19-9 ＋ CA242＋CA125- CEA and C12 combination detection（P〈0.05）. Reincreasing the detection combinations did not elevate the positive detection rate signifcantly. Conclusion C12 multi-tumor markers protein biochip has some clinical value in diagnosing alimentary tumors. But it is necessary to develop new multi-tumor markers protein biochip system which is more direct and pragmatic in order to improve its clinical pragmatic value.