286株临床分离大肠埃希菌耐药特征分析

Analysis of drug-resistance characteristics in 286 clinical isolates of Escherichia coli

目的探讨大肠埃希菌耐药情况,以指导临床合理使用抗菌药物。方法对2009～2010年从临床标本中分离的286株大肠埃希菌的耐药情况进行回顾性分析。结果大肠埃希菌对多种常用抗菌药物耐药率高,亚胺培南、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、阿米卡星耐药率低,其中亚胺培南对大肠埃希菌100%敏感。大肠埃希菌产超广谱β-内酰胺酶检出率为39.2%。结论大肠埃希菌对常用抗菌药物耐药率高,应加强其耐药监测,合理使用抗菌药物。

Objective To investigate the drug resistance status of Escherichia coli（Eco） clinical isolates from our hospital and to provide scientific evidence for rational use of antibiotics. Methods 286 strains of Eco were isola- ted from clinical samples during 2009--2010 and the retrospective analysis was performed. Results The different drug-resistances to commonly used antibiotics occurred in clinical isolates of Eco, The resistance rate of imipenem, ce- foperazone/sulbactam,piperacillin/tazobactam and arnikacin was low. There was no strain resistant to carbopenems such as imipenem. The detection rate of extended spectrum β lactamase（ESBLs） producing Eco was 39.2. Conclusion The drug-resistance status of Eco in our hospital is very serious. We should attach importance to monitor and control the spread and prevalence of the drug-resistance bacteria.