异甘草酸镁治疗慢性乙型肝炎36例疗效分析

Clinical Analysis for Magnesium Isoglycyrrhizinate in the Treatment of Chronic Hepatitis

目的探讨异甘草酸镁治疗慢性乙型肝炎患者的临床价值。方法把72例慢性乙型肝炎患者随机分为治疗组及对照组,每组36例,治疗组给予异甘草酸镁治疗,对照组给予甘草酸二胺治疗,比较分析各组患者治疗前后肝功能水平变化及临床症状改善情况。结果治疗组与对照组相比,ALT、AST及TBIL水平降低更明显,临床症状改善较明显,差异均具有统计学意义(P均<0.05)。结论异甘草酸镁治疗慢性乙型肝炎疗效确切,值得临床推广应用。

Objective To observe the efficacy of magnesium isoglycyrrhizinate in the treatment of chro-nic hepatitis. Methods 72 patients with chronic hepatitis B were randomly divided into treatment group and control group. The 36 hepatitis sufferers were treated with 100mg magnesium isoglycyrrhizinate added into 250ml 10% glucose injection liquid, and the other 36 sufferers control group were treated with compound Glyeyrrhizin 150mg added into 250ml 10% glucose injection liquid, I. V. drip, once a day for 1 month. When the treatment was over, the practical effects were analyzed. Results The levels of ALT, AST and TBIL dropped more rapidly than those in control group and there was significant difference in symptom improvement between treatment group and control group （ P 〈 0.05 ）. Conclusion Clinic symptom and liver function index can be improved after treatment with magnesium isoglycyrrhizinate injection in chronic hepatitis sufferers, and there are few side reactions happened.