半胱氨酸蛋白酶抑制剂C对肿瘤患者早期肾功能损害的评估价值

Value of Detection of Serum Cystain C in Early Renal Impairment of Cancer Patients

目的:探讨检测血清半胱氨酸蛋白酶抑制剂C(Cys C)水平对肿瘤患者早期肾功能损害的诊断价值。方法:对811例住院肿瘤患者进行血清肌酐(Scr)、尿素(Urea)和Cys C测定,按照简化的MDRD方程计算估算的肾小球滤过率(eGFR)并将其分为5组。结果:各组Cys C、Scr和Urea随eGFR的降低逐渐升高,Cys C在各组间差异均有统计学意义(P<0.05),而Scr。和Urea在前三组中差异无统计学意义(P>0.05)。在eGFR<60时,Cys C和Scr异常率间差异无统计学意义(P>0.05),eGFR≥60时,两者异常率差异有统计学意义(P<0.05)。结论:Cys C能反映早期肾功能损害,敏感性高于Scr,是反映肾小球滤过功能的理想指标。

Objective： To explore the diagnostic value of serum cystain C in early renal impairment of cancer patients. Methods： Serum creatinine （ Ser）, Urea and Cystain C （ Cys C） were measured simultaneously in 811 inpatients. Estimated glomerular filtration（eGFR） was calculated using the abbreviated Modification of Diet in Renal Disease（MDRD） and was grouped into 5 stages. Re- suits： The average levels of Cys C,Scr and Urea increased as eGFR decreasd gradually. The level of Cys C showed a significant difference （ P 〈 0. 05） between different stages, while no significant difference was found of the level of Ser and Urea in the front 3 stages （P 〉 0. 05 ）. In eGFR 〈 60 stage, there was no significant difference of the abnomal rates of Scr and Cys C , while significant difference was found in eGFR≥60 stage. Conclusion： Cys C can reflect early renal impairment which is more sensitive than Scr. It is an ideal marker in evaluating GFR.