塞来昔布联合盐酸乙哌立松治疗急性腰扭伤40例

40 Cases of Acute Lumbar Muscle Sprain Treated with Celecoxib plus Eperisone Hydrochloride

目的观察塞来昔布联合盐酸乙哌立松治疗急性腰扭伤的临床疗效。方法急性腰扭伤患者72例,随机分为治疗组40例和对照组32例,对照组第1天给予塞来昔布400 mg,bid,从第2天开始每次200 mg,bid,饭后服用,6 d;治疗组同时联合应用盐酸乙哌立松50 mgt,id,饭后服用7,d。比较两组治疗第7,14天的治疗效果。结果治疗组和对照组治疗第7天优良率分别为90.0%,75.0%(P<0.05);第14天优良率分别为95.0%,93.8%(P>0.05)。结论塞来昔布联合盐酸乙哌立松在早期可以迅速缓解急性腰扭伤患者症状,中远期两者疗效差异无统计学意义。

Objective To assess the clinical efficacy of celecoxib combined with eperisone hydroehloride for treating acute lumbar muscle sprain. Methods Among 72 cases with acute lumbar muscle sprain, 32 were treated with celecoxib 400 mg bid at the first day, and then with celecoxib 200 mg bid for 6 days;40 were treated with celecoxib combined with eperisone hydrochloride 50 mg tid for 7 days. The clinical effect and the adverse drug reaction at the 7th and 14th day were recorded. Results At the 7th day, the excellent and good therapeutic rate was 90.0% in the experimental group and 75.0% in the control group（P〈0.05）. While at the 14th day, the excellent and good therapeutic rate was 95.0% in the experimental group and 93. 8% in the control group（ P〉0.05 ）. Conclusion The clinical effect of celecoxib combined with eperisone hydrochloride would be more effective than monotherapy for acute lumbar muscle sprain in early period;there are no significant differences between the two treatments in later period.