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细胞凋亡显像剂[^(18)F]FEDPA的合成和标记 被引量：1

Synthesis and Radiolabelling of [^(18)F] FEDPA as an Imaging Agent for Apoptosis
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摘要 为制备新型细胞凋亡显像剂[18F]FEDPA,合成了前体(2-{2-[2-(3,5-二-N,N-二(2-甲基吡啶)氨甲基-苯氧基)乙氧基]-乙氧基}乙基)-胺,总收率5%(以化合物4计)。后经过18F标记合成[18F]FEDPA,标记率(8.9±0.3)%(经校正,n=2),HPLC检测其放射化学纯度为77%。 Synthesis and fluoro-radiolabelling of apoptosis imaging agent [^（18）F] FEDPA were reported.The labeling precursor 2-{2-[2-（3,5-bis（2,2＇-dipicolyaminomeyhyl）-phenoxy）ethoxy]-ethoxy}ethyl amine was prepared with the total yield of 5%（based on compound 4）.18F-labeling of the precursor gave FEDPA.The radiochemical yield is（8.9±0.3）%（n=2,decay corrected） and radiochemical purity is 77% determined by HPLC.
作者 郭新艳 王红亮 金燕锋 刘英华 唐刚华 姜申德
机构地区 天津大学药物科学与技术学院 中山大学附属第一医院核医学科PET-CT中心
出处 《核化学与放射化学》 CAS CSCD 北大核心 2011年第4期245-251,共7页 Journal of Nuclear and Radiochemistry
基金 国家自然科学基金资助项目(30970856) 国家高技术研究发展计划(863计划)资助项目(2008AA02Z430)
关键词 18F-标记 细胞凋亡 [18F]FEDPA 合成 18F-labeling apoptosis [18F] FEDPA synthesis
分类号 TL923 [核科学技术—核燃料循环与材料]
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参考文献11

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二级参考文献15

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核化学与放射化学
2011年 第4期

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