sTfR与孕妇、新生儿、婴儿亚临床缺铁及缺铁性贫血前瞻性纵向研究

Forward-looking longitudinal study about sTfR with pregnant women,neonatal,infant's subclinical iron deficiency and iron deficiency anemia

【目的】通过前瞻性纵向监测贫血孕妇及其新生儿、婴儿的Hb,sTfR,分析孕妇贫血对婴儿6月龄时铁代谢的影响。【方法】随机抽取Hb<100 g/L的56例临产孕妇作为研究组,选取56例Hb>110 g/L的同孕周临产孕妇作为对照组,两组孕妇所生各56例新生儿、婴儿为子代研究组、子代对照组,婴儿于出生时、42 d、4个月、6个月进行定期体检,孕妇、新生儿、6月龄婴儿抽血检测Hb、sTfR。【结果】与对照组比较,贫血孕妇及其所生婴儿6月龄时的Hb、sTfR值差异有统计学意义(P<0.01),新生儿Hb、sTfR值差异无统计学意义(P>0.05)。贫血孕妇所生婴儿6月龄时IDA检出率为60.8%%,正常孕妇所生婴儿为21.6%,差异有统计学意义(P<0.01)。【结论】孕妇贫血是导致6月龄婴儿SID及IDA的主要危险因素。

[Objective] Through the forward looking longitudinal monitoring anemia pregnant women and neonatal, infant＇s Hb, sTfR, to analysis the influence of iron metabolism of 6 months infant when pregnant women suffering from a- nemia. [Methods] Randomly selected 56 cases parturient women which Hb 〈100 g/L as study group, another 56 cases parturient women with gestational age at birth which Hb 〉110 g/L as control group. Their neonates were divided into two groups： progeny study group and progeny control group. Babies were regular check-up at birth, 42^nd day, 4^th month, 6^th month. All of them were extracted blood testing Hb, sTfR. [Results] Compared with controls, the pregnant women and 6 months old babies＇ Hb and sTfR value had very significant differences（P〈0.01） . Neonatal Hb and sTfR value had no significant differences（P〈0. 05）. Anemia pregnant women＇s babies of 6 months old, 60.8% suffered from IDA. The normal pregnant women＇s babies, only 21.6% suffered from IDA. Difference was very significant（P〈0.01）. [Conclusion] Pregnant women anemia is one of risk factors to cause 6^th month infant subclinical iron deficiency and IDA.