降脂护肝丸治疗非酒精性脂肪肝疗效分析

Clinical Study of Traditional Chinese Herb Tablet Jiangzihugan bills on NAFLD

目的探讨中药制剂治疗非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)的疗效及影响因素分析。方法观察NAFLD病例212例,随机分为治疗组(114例)和对照组(98例)。治疗组给予中药制剂降脂护肝丸口服,6g,3/d;对照组给予凯西莱加护肝片口服;均连服6个月。观察两组治疗前后肝功能、血脂、B超影像学的改变。结果治疗后,两组肝功能检测指标均有改善,两组间差异无统计学意义。治疗组三酰甘油由(2.7±1.1)mmol/L降至(1.7±0.3)mmol/L(P<0.05),总胆固醇由(5.3±0.8)mmol/L降至(4.7±0.8)mmol/L(P<0.05);肝B超影像学征象减轻率为56.1%,复常率为25.4%,有效率为81.6%;均明显优于对照组(P<0.05,P<0.01)。结论中药制剂降脂护肝丸能有效改善NAFLD患者的肝功能、血脂和B超影像学,疗效明显优于常规治疗。

Objective To study the clinical efficacy and mechanism of traditional Chinese herb tablet Jiangzihugan bills on nonalcoholic fatty liver disease（NAFLD）. Methods Totally 212 cases were randomly divided into treatment group（114 cases）and control group（98 cases）. The treatment group received oral administration of traditional Chinese herb tablet for liver lipid-lowering a- gents,each 6 grams,3 times a day. Control group was treated with Tiopronin arid hugan tablets for 6 months. The changes of liver function,blood lipids and liver ultrasonography were observed before and after treatment. Results Decrement of ALT,AST was no significant difference in the two groups. The symptoms improved, blood lipid in the treatment group were significantly difference compared with the control group （P〈0.01）. With Jiangzihugan bill before and after treatment in the treatment group,TG levels [ （2.7±1.1） mmol/L vs （1.7±0.3）mmol/L]and TC levels [ （5.3±0.8）mmol/L vs （4.7±0.8）mmol/L] were significantly decrease （P〈0.05）. The improvement rate waw 56.1% and disappearance rate was 25.4% in the liver image change of ultrasonography. Conclusions Traditional Chinese Herb Tablet Jiangzihugan bills can improve the nonlcoholic fatty liver in patients with liver f, nction, blood lipids, and improve the uhrasonograpy image,more effective than the routine treatment group.