翻白草水提取物对自发2型糖尿病db/db小鼠降糖作用的研究

Anti-aiabetic effect of aqueous extract of Potentilla discolor Bunge on db/db mice

目的观察翻白草水提取物对2型糖尿病db/db小鼠空腹血糖、血清胰岛素及胰岛素敏感指数的影响。方法采用公认的自发2型糖尿病模型db/db小鼠,随机分为4组:翻白草高剂量组(400mg·kg-1·bw-1)、翻白草低剂量组(200mg·kg-1·bw-1)、吡格列酮组(4.05mg·kg-1·bw-1)及模型组,每组6只。另取db/m小鼠6只为正常组。比较各药物干预4周后对小鼠空腹血糖、血清胰岛素水平以及胰岛素敏感指数的影响。结果翻白草提取物和吡格列酮组均可显著降低小鼠空腹血糖、血清胰岛素水平,增加胰岛素敏感指数(P<0.05)。结论翻白草对自发2型糖尿病db/db小鼠的空腹血糖及血清胰岛素水平有一定调节作用。

Objective To observe the effects of aqueous extract of Potentilla discolor Bunge（APB） on fasting blood glucose（FBG）,serum insulin（FINS） and insulin sensitivity index（ISI） in type 2 diabetic C57BL/KsJ db/db mice.Methods The universally accepted spontaneous type 2 diabetic animal model：db/db mice were randomly divided into 4 groups（n = 6）：the high dose APB group（400 mg·kg^-1·bw^-1）,low dose APB group（200 mg·kg^-1·bw^-1）,Pioglitazone group（4.05 mg· kg^-1·bw^-1） and model group,another six db/m mice as normal control group.Compare the level of fasting blood glucose,serum insulin levels and insulin sensitivity index in each group after 4 weeks of treatment.Results Both the APB aqueous extract and the Pioglitazone group significantly decrease FBG,FINS,and increase ISI（P 0.05）.Conclusion Aqueous extract of Potentilla discolor Bunge.may offer an alternate treatment for diabetes by regulating fasting blood glucose and serum insulin levels on the spontaneous type 2 diabetic db/db mice.