摘要
目的:探讨大鼠急性重症胰腺炎(SAP)与肠黏膜屏障的关系以及鱼油干预的影响,为临床营养支持提供依据。方法:用3.5%牛磺胆酸钠逆行胰胆管注射法诱导SAP模型。48只成熟SD大鼠造模成功后分为两组,生理盐水组(A组,n=24),鱼油干预组(F组,n=24),分别于造模后给予尾静脉营养支持,与实验后6、12、24h分别处死各组的其中8只大鼠,观察各自胰腺、小肠病理变化并测定其血清内毒素浓度。结果:F组门静脉血内毒素水平低于A组(P<0.05);F组肠道损伤评分低于A组(P<0.05)。结论:添加静脉鱼油营养支持能降低SAP时门静脉血中的内毒素水平、促进肠道黏膜的修复、加强肠黏膜屏障的保护作用。
Objective：To investigate the protective effect of fish oil on intestinal mucosa barrier in severe acute pancreatitis （SAP） rats.Methods：48 SD rats were divided into 2 groups at random （A,F）,24 in each group,group A was given saline water,group F was given fish oil,established model of intestinal injury after feeding rats 6 hours,then group A was given saline water,group F was given fish oil untill be killed.To measured concentration of endotoxin （ET） in portal vein blood supernatant after 6,12 and 24 hours.Results：Serum ET concentration in group F was significantly lower than group A （P0.05）.The degree of injury of intestinal mucosa was much lower in group F than group A.Conclusion：The fish oil can prevent the intestinal mucosa barrier in SAP.
出处
《中国当代医药》
2011年第10期20-21,共2页
China Modern Medicine
关键词
鱼油
肠黏膜屏障
内毒素
急性重症胰腺炎
Fish oil
Intestinal mucosa barrier
Endotoxin
Severe acute pancreatitis
