逍遥煎剂对腹泻型肠易激综合征大鼠血清5-HT、NO的影响

Effects of Xiaoyao Decoction on Serum 5-HT and NO of Rats with Diarrhea-predominant Irritable Bowel Syndrome

目的:观察逍遥煎剂对腹泻型肠易激综合征大鼠血清5-HT、NO的影响。方法:将60只大鼠随机分为正常组、模型组、曲美布汀组、逍遥煎剂低、中、高剂量组6组,每组10只,除正常组外各组均复制肠易激综合征模型,2周后,加用相应的药物治疗,观察各组大鼠10 d、20 d后血清5-HT、NO的变化。结果:各组大鼠治疗10 d后5-HT,NO与模型组比较有显著差异(P<0.05),各组之间比较无显著性差异,治疗20 d后5-HT,NO与模型组比较有显著差异(P<0.05),逍遥煎剂高剂量组与曲美布汀组比较有显著性差异(P<0.05)。结论:逍遥煎剂有显著的止泻作用,逍遥煎剂治疗肠易激综合征可能与5-HT、NO的改变有关。

Objective ： To observe the effects of Xiaoyao Decoction on serum 5 - HT and NO of rats with diarrhea-predominant irritable bowel syndrome. Method： 60 rats were randomly divided into six groups： the normal group, model group, trimebutine group, Xiaoyao Decoction groups of LD, HD and MD respectively, ten rats in each group. Except for the normal group, five oth- er groups were copied the model of irritable bowel syndrome, and two weeks later, they were given the corresponding treatment. The difference of serum 5 - HT and NO of the rats of each group were observed 10 and 20 days later. Results ： Compared with the model group, there was significant difference in serum 5 -HT and NO in each group after 10 days of treatment （P 〈0.05 ）, and there was no obvious difference among the five treatment groups. Compared with the model group, there was significant difference in serum 5 - HT and NO in each group after 20 days of treatment （P 〈0.05） , there was a significant difference between Xiaoyao Decoction group and trimebutine group （P 〈0.05 ）. Conclusion： Xiaoyao Decoction has a significant antidlarrheic effect, and its effect on irritable bowel syndrome may be related with the change of 5 - HT and NO.