摘要
中枢神经系统(CNS)损伤后因胶质瘢痕形成而导致神经元的轴突不能再生,功能恢复不良。胶质瘢痕的重要组分是硫酸软骨素蛋白聚糖(CSPGs),其单独或与其它细胞外基质结合,导致向损伤部位延伸的轴突在胶质瘢痕处停止,而且CSPGs在神经再生时间窗关键期末可降低轴突生长的可塑性。近年研究发现硫酸软骨素酶ABC(chondroitinase ABC,ChABC)能通过降解CSPGs,使轴突的再生能力加强,活化轴突生长的可塑性,促进CNS损伤后的运动功能恢复。本文综述了近年来ChABC对中枢神经系统神经再生和可塑性作用的研究进展。
Following the mammalian central nervous system （CNS） injuries, it is very difficult for the axons of the neurons to regenerate and recover due to the restricted neural plasticity by the glial scar. Axon regeneration is inhibited by the presence of various inhibitory molecules, including chondroitin sulfate proteoglycans （CSPGs）. Plasticity after the end of critical period is also restricted by CSPG. Chondroitinase ABC promotes axonal regeneration and reactivates the axonal plasticity. This review summarizes the role of the chondroitinase ABC in promoting neural regeneration and plasticity in central nervous system.
出处
《解剖科学进展》
CAS
2011年第5期484-486,共3页
Progress of Anatomical Sciences
基金
高等学校博士学科点专项基金(No.20070159016)
