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巯嘌呤甲基转移酶遗传多态性的研究进展

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摘要 临床上巯嘌呤类药物应用广泛,但此类药物的血液毒性、肝脏毒性、胰腺炎等不良反应的发生率较高。研究发现,巯嘌呤甲基转移酶(TPMT)的遗传多态性与巯嘌呤类药物不良反应的发生密切相关。在使用巯嘌呤类药物之前对患者进行酶活性测定及基因型分析,可为指导临床个体化、安全用药提供依据。
作者 胡凤侠 普雄明
机构地区 新疆医科大学研究生院 新疆维吾尔自治区人民医院皮肤性病科
出处 《中国麻风皮肤病杂志》 2011年第8期561-563,共3页 China Journal of Leprosy and Skin Diseases
关键词 巯基嘌呤甲基转移酶 遗传多态性 巯嘌呤类药物
分类号 R96 [医药卫生—药理学]
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参考文献17

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二级参考文献35

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共引文献11

中国麻风皮肤病杂志
2011年 第8期

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